Effect of abdominal obesity on insulin resistance and the components of the metabolic syndrome: Evidence supporting obesity as the central feature
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Date
2003
Authors
Türkoğlu, Çavlan
Duman, Belgin Süsleyici
Günay, Demet
Çağatay, Penbe
Ozcan, Remzi
Buyukdevrim, Ahmet Sevim
Journal Title
Journal ISSN
Volume Title
Publisher
F D-Communications Inc.
Abstract
Background: Metabolic syndrome includes abdominal obesity diabetes type 2 hypertension dyslipidemia derangements of fibrinolysis and atherosclerosis. Since abdominal obesity is one of the major components of the insulin resistance syndrome (IRS) an attempt was made to evaluate the interrelationships between the magnitude of obesity and the components of the syndrome. Methods: A cross-sectional study of 123 subjects with type 2 diabetes of whom M were normal body weight and 92 had varying degrees of obesity was conducted. The participants were investigated in terms of clinical and laboratory findings of IRS. Fasting and 30-min (early) plasma glucose and serum insulin excursions in response to oral glucose challenge (75 g) were determined. The peripheral and hepatic insulin resistance (insensitivity) was calculated by homeostasis model assessment (HOMA). Results: Clinical and biochemical findings were compared with the components of the IRS and demonstrated that a rise in fasting as well as 30-min insulin secretion increases as abdominal body fat (obesity) increases. There was also a significant and proportional correlation between the magnitude of abdominal obesity and the components of metabolic syndrome. Conclusion: Abdominal adiposity appears to have a pivotal role in the development of IRS.
Description
Keywords
Obesity, Hyperinsulinemia, Insulin resistance, Macro- and microangiopathy, Metabolic syndrome, Diabetes type 2, Morbid obesity
Turkish CoHE Thesis Center URL
Citation
39
WoS Q
Q1
Scopus Q
Q1
Source
Volume
13
Issue
5
Start Page
699
End Page
705