Browsing Mühendislik ve Doğa Bilimleri Fakültesi by Title
Now showing items 328-347 of 750
-
Homology modeling andin silicodesign of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes
(2020)Histone deacetylases (HDACs) are a group of enzymes that have prominent and crucial effect on various biological systems, mainly by their suppressive effect on transcription. Searching for inhibitors targeting their ... -
Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors
(Taylor & Francis Inc, 2019)Histone deacetylases (HDACs) are implicated in the pathology of various cancers, and their pharmacological blockade has proven to be promising in reversing the malignant phenotypes. However, lack of crystal structures of ... -
Hourly electricity demand forecasting using Fourier analysis with feedback
(Elsevıer, 2020)Whether it be long-term, like year-ahead, or short-term, such as hour-ahead or day-ahead, forecasting of electricity demand is crucial for the success of deregulated electricity markets. The stochastic nature of the demand ... -
How an Inhibitor Bound to Subunit Interface Alters Triosephosphate Isomerase Dynamics
(Cell Press, 2015)The tunnel region at triosephosphate isomerase (TIM)'s dimer interface distant from its catalytic site is a target site for certain benzothiazole derivatives that inhibit TIM's catalytic activity in Trypanosoma cruzi the ... -
Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities
(Taylor & Francis Inc, 2019)Parkinson's disease (PD) is characterized by the loss of dopamine-generating neurons in the substantia nigra and corpus striatum. Current treatments alleviate PD symptoms rather than exerting neuroprotective effect on ... -
A hybrid approach to concept selection through fuzzy analytic network process
(Pergamon-Elsevier Science Ltd, 2009)Evaluating conceptual design alternatives in a new product development (NPD) environment has been one of the most critical issues for many companies which try to survive in the fast-growing world markets. Therefore most ... -
A hybrid approach to machine-tool selection through AHP and simulation
(Taylor & Francis, 2007)The selection process of a machine tool has been a critical issue for companies for years because the improper selection of a machine tool might cause many problems having a negative effect on productivity precision ... -
Hybrid MEMS-Based molecular communication system
(Institute of Electrical and Electronics Engineers Inc., 2019)In this paper, we consider a molecular communication link integrated in a micro-electro mechanical system (MEMS) based environment. We apply acoustic tweezing techniques to the molecular communication system to increase ... -
Hybrid MPI plus UPC parallel programming paradigm on an SMP cluster
(TUBITAK Scientific & Technical Research Council Turkey, 2012)The symmetric multiprocessing (SMP) cluster system which consists of shared memory nodes with several multicore central processing units connected to a high-speed network to form a distributed memory system is the most ... -
Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets
(Frontiers Media, 2020)Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human species, were explored to identify potential allosteric ... -
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies
(Elsevier, 2020)Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator Methionine from the nascent polypeptides. MetAPs are classified into two isoforms: namely, ... -
Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
(Taylor & Francis Inc, 2018)Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer ... -
IEEE 802.15.4a Based Ultra Wideband Systems for Coexistence with Primary Users
(IEEE, 2015)Peaceful coexistence is a major implementation issue for both cognitive radios and ultra wideband (UWB) systems. Accordingly the UWB impulse radio (UWB-IR) based Wireless Personal Area Network (WPAN) standard IEEE 802.15.4a ... -
IEEE 802.15.7r1 Reference Channel Models for Visible Light Communications
(IEEE-Inst Electrical Electronics Engineers Inc, 2017)The IEEE has established the standardization group 802.15.7r1 "Short Range Optical Wireless Communications", which is currently in the process of developing a standard for visible light communication (VLC). As with any ... -
Implementation of a SDN (Software defined network)
(International Institute of Informatics and Systemics IIIS, 2014)Improving resource efficiency enhancing network security and achieving simpler network management have become the main goals for networking in the previous years. To accomplish these ideas an efficient routing traffic ... -
Importance of Regional Differences in Brain Throughout Aging for Down Syndrome
(Association for Computing Machinery, 2018)Down syndrome (DS) which affects approximately one in 700 live births is caused by an extra copy of the long arm of human chromosome 21 (HSA21). Statistical analysis has been done for understanding the protein expression ... -
An Improved Adaptive Subspace Tracking Algorithm Based on Approximated Power Iteration
(IEEE-INST Electrical Electronics Engineers Inc, 2018)A subspace tracking technique has drawn a lot of attentions due to its wide applications. The main objective of this approach is to estimate signal or noise subspace basis for the sample covariance matrix. In this paper ... -
Improvement of indoor positioning accuracy of ultra-wide band sensors by using big bang-big crunch optimization method
(Pamukkale Univ, 2018)Ultra-wide Band technology is an emerging technology that offers successful solutions in many indoor positioning systems and performs better than other methods. In this study an indoor positioning system using Ultra-wide ... -
Improving Energy-Efficiency of WSNs through LEFCA
(Sage Publications Inc, 2016)Wireless sensor networks (WSNs) have become an important part of our lives as they can be used in vast application areas from disaster relief to health care. As a consequence the life span and the energy consumption of a ... -
Improving OpenCL programmability with the Heterogeneous Programming Library
(Elsevier Science Bv, 2015)The use of heterogeneous devices is becoming increasingly widespread. Their main drawback is their low programmability due to the large amount of details that must be handled. Another important problem is the reduced code ...
