WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://gcris.khas.edu.tr/handle/20.500.12469/4465

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Citation Count: 30
Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation
(Arnold Hodder Headline Plc., 1999) Yılmaz, Mert; Ener, Serdar; Akalın, Halis; Sağdıç, Kadir; Serdar, O. Akin; Cengiz, Mete
The systemic inflammatory response to cardiopulmonary bypass (CPB) is associated with increased production of cytokines. This systemic inflammatory response characterized by the activation of interleukin-6 (IL-6) and interleukin-8 (IL-8) during and after CPB is well documented. A prospective randomized double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (MPSS) on the circulating levels of serum cytokines and clinical outcome. Twenty patients were randomly divided into two groups on the basis of the administration of low-dose(1 mg/kg) MPSS in = 10) and placebo in = 10) into the pump prime solution. All patients were scheduled to undergo a primary
Citation Count: 0
Does different orientation of the Medtronic Hall tilting disc valve in the aortic position effect transvalvuler pressure gradients?
(Medimond Srl, 2000) Güden, Metin; Akpınar, Belhhan; Sağbaş, Ertan; Sanisoğlu, İlhan; Arpaz, M.; Bayındır, Osman
The effect of valve orientation during aortic valve replacement (AVR) with the Medtronic Hall (MH) tilting disc valve on transvalvuler pressure gradients was evaluated. 30 patients (pts) undergoing isolated AVR received a MH which was oriented so that the greater opening of the valve faced the non coronary aortic sinus. There were 12 male and 8 female pts in this group with a mean age of 59 +/- 5.2 years. An echocardiographic examination was performed 6 days after the operation and resting transvalvuler gradients were measured (Group 1). The gradients were compared with the results of 30 pts. who had undergone AVR with the same valve previously but with the orientation of the greater opening towards the left or the right coronary sinus (Group 2). In Group 1 the mean valve size was 22 mm. and the measured mean valvuler gradient was 24/13 mmHg (peak/mean). In Group 2 the mean valve size was 22.1 mm. and the measured mean valvuler gradient was 31/20 mmHg (peak/mean). Student's t test was used for statistical analysis and transvalvular gradients in Group 1 were found to be significantly lower than Group 2 (p>005). Implantation with greater opening of the tilting mechanical valve facing the non-coronary sinus seems to result in lower transvalvuler gradients than other orientations.
Citation Count: 21
Going against the national cultural grain: a longitudinal case study of organizational culture change in Turkish higher education
(Carfax Publishing, 2000) Herguner, Gülten; Reeves, Nigel B.R.
This paper presents results of a longitudinal case study inquiry into the measurement of organizational culture change through the implementation of total quality management (TQM) concepts in a higher education context. The inquiry deals with the relationship between national culture and the company corporate culture the consequences of manager style change for TQM implementation and how culture change can be measured adequately. The results are achieved by the utilization of external (quantitative) and internal (qualitative) measurement devices. Limitations consequent upon the number of participants and the dual role of the researcher indicate the potential value of further investigations into the topic using these devices. The main conclusion is that the maintenance of TQM systems without continued senior managerial commitment may not suffice to secure change and prevent a reversion to earlier cultural patterns. Certainly since the findings of this inquiry are limited to one case study it would be unwise to assume that similar results would necessarily pertain in other higher education contexts. Nevertheless we are of the view that the findings are suggestive of the pressures imposed on organizational change by national cultural patterns. The devices implemented for measuring organizational cultural change while not designed for that purpose have however yielded sufficiently well-defined results to suggest the value of similar implementations to gain insight into the topic in further higher education and other organizational contexts.
Citation Count: 23
The use of the 5-HT3-receptor antagonist ondansetron for the treatment of postcardiotomy delirium
(W.B. Saunders Co Ltd, 2000) Bayındır, Osman; Akpınar, Belhhan; Can, Erol; Güden, Mustafa; Sönmez, Bingür; Demiroğlu, Cemşid
Objective:To evaluate the effect of the 5-HT3-receptor antagonist ondansetron in patients with postcardiotomy delirium. Design: Prospective study. Setting: University hospital. Participants: Thirty-five patients who had undergone coronary artery bypass graft surgery. Interventions: Thirty-five patients 23 men and 12 women who developed delirium in the intensive care unit after coronary artery bypass graft surgery were included. Mean patient age was 51.3 years (range 36 to 79 years). A mental status scoring scale was developed and patients were scored 0 to 4 according to their delirium status after confirming that there were no correctable metabolic abnormalities as an underlying cause for delirium. Normal behavior was scored as 0 and severe verbal and physical agitation was scored as 4. Patients received a single dose of ondansetron 8 mg intravenously and were reevaluated 10 minutes later. Measurements and Main Results: Before the treatment 7 patients had a score of 2 (20)
Citation Count: 33
Primary epiploic appendagitis CT manifestations
(Elsevier Science Inc, 2000) Şırvancı, Mustafa; Tekelioğlu, Mehmet H.; Duran, Cihan; Yardımcı, Hakan; Onat, Levent; Özer, Kadir
Inflammation of an epiploic appendage is considered to be a rare cause of acute abdomen. Recently it has been reported that typical computed tomography (CT) findings of primary epiploic appendagitis (PEA) provide a definitive diagnosis in most of the cases. However since these papers are only few they are easily overlooked by the practicing radiologists. Our purpose is to add four new cases to the existing literature and to perform a review of the literature. (C) 2001 Elsevier Science Inc. All rights reserved.
Citation Count: 4
Association of lipoprotein(a) concentration and apo(a) isoform size with restenosis after percutaneous transluminal coronary angioplasty
(Springer Verlag, 2000) Sırıkcı, Onder; Aytekin, Vedat; Demiroglu, I. C. C.; Demiroğlu, Cemşid; Marcovina, S.M.
Lp(a) is a unique class of lipoprotein particles that exhibits a considerable size heterogeneity resulting from the size polymorphism of apo(a) its unique protein component. An elevated level of Lp(a) in plasma has been proposed to be a risk factor for premature development of coronary artery disease. To evaluate the relationship between Lp(a) concentration and apo(a) isoform size with restenosis after percutaneous transluminal coronary angioplasty Lp(a) levels and apo(a) phenotypes were determined in 204 patients who underwent a successful coronary angioplasty procedure and stent implantation. The patients were followed with clinical examinations and exercise tests at 1 3 and 6 months and a control coronary angiography was performed after 6 months to evaluate restenosis. Lp(a) levels were determined with an ELISA that is insensitive to the size heterogeneity of Lp(a) and the apo(a) isoforms were determined by a high-resolution agarose gel electrophoresis method followed by immunoblotting with a specific monoclonal antibody. Of the 146 patients who underwent angiographic evaluation 57 (39%) had restenosis whereas 89 (61%) did not. Lp(a) levels and the distribution of the expressed apo(a) phenotypes were compared in these two groups of patients. Although the mean and median Lp(a) levels were higher in the restenosed group the difference was not statistically significant. However a significant difference in Lp(a) values was found in women (P=0.043) even though because of the small number of women in the study (n=35) no sound conclusions can be reached on the predictive role of Lp(a) in restenosis. There also was no difference in the distribution of apo(a) phenotypes between the two groups. Because of their wide distribution Lp(a) values and apo(a) isoforms do not seem to be a useful indicator of risk of restenosis after percutaneous transluminal coronary angioplasty in our study cohort.
Citation Count: 5
Presence and localization of connexins 43 and 26 in cell cultures derived from myometrial tissues from nonpregnant and pregnant women and from leiomyomas
(Mosby-Elsevier, 2000) Ciray, Haydar Nadir; Fu, Xin; Olovsson, Matts; Ahlsen, Goran; Shuman, Cheryl; Lindblom, Bo; Ulmsten, Ulf
OBJECTIVE: Our objective was to study the appearance and distribution of connexins 43 and 26 in various human myometrial cell cultures. STUDY DESIGN: Scrape loading Western blotting and immunohistochemical techniques were applied to cultured cells derived from myometrial tissues obtained from nonpregnant and pregnant women (upper and tower uterine segments) and from leiomyomas (tumor and analogous myometrial tissues). RESULTS: Scrape loading revealed the presence or metabolic coupling in all tissues. indirect immunohistochemical studies showed membrane localization of connexin 43 in all myometrial cultures. Western blots and indirect immunohistochemical studies showed the presence and localization of the connexin 26 protein and associated gap junctions in tissues from myomas and from nonpregnant and pregnant women except for those derived from the upper segment of the pregnant uterus. CONCLUSION: These results show that human myometrial cultures express various gap junction proteins and that there are regional differences in expression of connexins in tissues from pregnant women.
Citation Count: 20
In situ split costal cartilage graft harvesting through a small incision using a gouge
(Lippincott Williams & Wilkins, 2000) Ağaoğlu, Galip; Erol, O. Onur
A costal cartilage graft is one of the most useful materials in reconstructive plastic surgery. In this article a technique of in situ split costal cartilage graft harvesting through a small incision (2 to 3 cm) using a gouge is described. The technique used has many advantages: it is a simple technique is easy to learn and can be performed quickly through a small incision. By avoiding complete costal cartilage graft harvesting the associated potential complications such as pleural perforation chest wall deformities long-lasting postoperative pain and incisional scar length are reduced. This technique will be useful in selected cases for which a complete block of costal cartilage graft is not needed.
Citation Count: 0
Intraoperative thermal coronary angiography: quality control
(Medimond Srl, 2000) Sönmez, Barış; Tansal, Selim; Yagan, N.; Ünal, M.; Arbatlı, Harun; Korkut, K.; Demirsoy, Ergun; Bayındır, Osman
Per operative coronary angiography has always been desired by coronary surgeons. Direct coronary angiographic imaging is not practical since needs contrast injection requires radiation and excessive technology with experienced staff which adds more expenses. Thermal angiography device IVA-2000 (OPGAL) is started to be used in our coronary bypass operations as a routine procedure. Thermal imaging provides an effective and real time coronary angiograms which provides very clear coronary angiograms as well as graft flows. The temperature differences generated in between the myocardium and the coronary arteries by injecting cold cardioplegic solution into the proximal end of the vein graft or by warm blood running through an internal thoracic artery graft creates an angiographic image and provides graft flow with termodilution technique after cross clamp released. Thermal images provided with thermal camera easy to tax no need for extra staff no side effects of contrast media to the patients and no radiation effect to the theatre stuff also. We will demonstrate basic principal of thermal camera and thermal coronary angiograms of different patients with different aspects.
Citation Count: 0
A synthesis tool for the multiplierless realization of FIR-based multirate DSP systems
(IEEE, 2000) Yurdakul, Arda
In this study a synthesis tool using a novel multirate folding technique which handles each FIR filter in a multirate DSP system as a single node is developed. A new architecture is presented for the multiplierless realization of a fold of multirate FIR filters. This synthesizer fully exploits the redundancies (i.e. `idle' and `missing' cycles) and common terms in multirate systems without sacrificing from overall system quality to produce multiplierless multirate systems. It also enables the usage of a single clock for all parts of the circuit.
Citation Count: 17
Off-pump coronary artery bypass grafting with use of the octopus 2 stabilization system
(2000) Akpınar, Belhhan; Güden, Mustafa; Sağbaş, Ertan; Sanisoğlu, İlhan; Aytekin, Vedat; Bayındır, Osman
Background: The treatment of coronary artery disease has evolved rapidly over the last two decades. The gold standard of surgical revascularization, the on-pump coronary artery bypass graft, has been challenged by the development of percutaneous transluminal coronary angioplasty. Our experience with the alternative of the off-pump ("beating heart") coronary artery bypass (OPCAB) technique during a period of 18 months suggests that OPCAB avoids the complications of cardiopulmonary bypass and offers patients the benefit of long-term graft patency that greatly exceeds that of current endovascular technologies. Methods: The early results of 126 OPCAB procedures performed through a medial sternotomy incision during a period of 18 months were evaluated. There were 80 male and 46 female patients, with a mean age of 69 +/- 4.3 years. Emergency cases and reoperations were not included. A total of 268 anastomoses were performed, with a mean number of 2.12 anastomoses per patient. Conduits used, with their percentage of use, were: left internal thoracic artery (LITA) (100%), right internal thoracic artery (11.1%), greater saphenous vein (84%), and radial artery (31%). In 72% of the cases, off-pump surgery was chosen because of patient risk factors such as atherosclerotic aortic disease, previous cerebrovascular accident or carotid artery disease, renal dysfunction, malignancy or poor left ventricular function. Results: There was no operative mortality. One-month postoperative mortality was three patients (2.3%). Two died because of mesenteric ischemia, and the other death was due to cardiac failure. Seventy-one patients had a control angiogram before discharge. The patency of LITA anastomosis was 100% while overall patency rate was 95%. In 43 patients for whom an angiogram could not be performed, a Thallum 201 stress test was performed three months postoperatively. Thirty-eight patients had a normal test while five patients showed signs of ischemia. These patients had a control angiogram: in four patients anastomoses were patent, but in one patient there was a severe narrowing of a venous anastomosis to the distal right coronary artery (RCA) which was corrected with angioplasty. In the whole series eight patients (6.3%) refused to have any control examination. Conclusions: Our early results suggest that off-pump CABG with Octopus 2 (Medtronic, Inc., Minneapolis, MN) can be a good alternative in high risk patients who need multiple vessel revascularization.
Citation Count: 0
Use of octopus 2 stabilization system for off-pump coronary artery bypass grafting
(Medimond S R L, 2000) Güden, M; Akpmar, B; Sagbas, E; Sanisoglu, I; Aytekin, V; Bayindir, O
The early results of 126 off pump CABG procedures performed through a median sternotomy incision (OPCAB) during a period of 18 months were evaluated. The mean age was 69+/-4.3 years. There were 80 male and 46 female patients. Emergency cases and reoperations were not included. A total of 268 anatomosis were performed with a mean number of 2.12 anastomosis Per patient. Conduits used were: LITA (100%), RITA (11.1%) GSV in (84%) and radial artery in (31%) of cases. In 72% of the cases, off pump surgery was chosen because of patient risk factors such as atherosclerotic aortic disease, previous CVA or carotid artery disease, renal dysfunction, malignancy and poor LV function. There was no operative mortality. One month mortality was 3 patients (2.3%). Two died because of mesentheric ischemia. 71 patients had a control angiogram before discharge. The patency of LITA anastomosis was 100% while overall patency rate was 95%. In 43 patients were an angiogram could not be performed, a Thalium 201 stress test was performed 3 months postoperatively. 38 had a normal test while 5 patients showed signs of ischemia. These patients had a control angiogram, in four patients anastomosis were patent, but in one patient tere was a severe narrowing of a venous anastomosis to the distal right coronary which was corrected with angioplasty. In the whole series 8 patients refused to have any control examination (6.3%). Our early results suggest that off pump CABG with Octopus stabilisation can be a good alternative in high risk patients who need multiple vessel revascularisation.
Citation Count: 1
Long-standing seroma after ultrasound-assisted liposuction
(Lippincott Williams & Wilkins, 2001) Ağaoğlu, Galip; Erol, O. Onur
[Abstract Not Available]
Citation Count: 0
An earthquake disaster in Turkey: Assessment of the need for plastic surgery services in a crisis intervention field hospital - Discussion
(Lippincott Williams & Wilkins, 2001) Pençe, Murat; Güney, Hasan Sadık; Ağaoğlu, Galip; Erol, O. Onur
[Abstract Not Available]
Citation Count: 8
Does off-pump coronary artery bypass surgery reduce mortality in high risk patients?
(Forum Multimedia Publishing LLC., 2001) Akpınar, Belhhan; Güden, Mustafa; Sanisoğlu, İlhan; Sağbaş, Ertan; Caynak, Barış; Bayramoğlu, Zehra; Bayındır, Osman
Background: The aim of this retrospective study was to compare outcome in two groups of patients who were classified according to their risk groups and underwent coronary revascularization with or without cardiopulmonary bypass. Material and Methods: Between January 1996 and July 2000 480 cases that underwent coronary artery bypass surgery (CABG) were included in a retrospective nonrandomized manner for study. Group I included 210 patients who were revascularized using off-pump techniques. Octopus 2 and 3 (Medtronic Inc. Minneapolis MN) were used for tissue stabilization. Group 2 included 270 cases who underwent CABG using CPB. Emergency cases combined operations reoperations and patients in cardiogenic shock were excluded. Demographic variables were comparable between two the groups. Using the Allegheny Clinic Risk Scoring Scale [Magovern 1996] patients in both groups were scored as low moderate and high risk. In Group 1 37% of patients consisted of high risk patients while Group 2 had 14% (p < 0.05) Student's t-test and chi-square test were used for statistical analysis and alfa < 0.05 was considered significant. Results: Mortality was 1.4% in Group 1 and 1.5% in Group 2 (p = ns). Mean anastomosis per patient was 2.6 +/- 0.6 in Group 1 and 3.2 +/- 0.5 in Group 2 (p < 0.05). Patients in Group I needed less blood transfusions and less inotropic support postoperatively (p < 0.05). There were also fewer minor neurological events (p < 0.05) and pulmonary complications (Type 2) in Group 1. Atrial fibrillation rate infection and major neurological deficit (Type 1) were similar in both groups. Mortality was less among Group 1 high risk patients (3.9%) in comparison to Group 2 high risk patients (7.9%) but this did not reach statistical significance. Conclusions: In low or moderate risk patients CABG can be performed safely with or without CPB. In high risk patients with several comorbidities off-pump CABG seems to be a safe and efficient method that can improve outcome.
Citation Count: 62
Interactions of polyacrylamide polymer with bentonite in aqueous systems
(Elsevier Science Bv, 2001) Güngör, Nurfer; Karaoğlan, S
The flow properties of natural Ca bentonite and Na bentonite-water systems were studied after adding an anionic polyacrylamide (PAM) polymer. The effect of the PAM has also been investigated at different quantities. The experimental results are discussed in terms of bentonite forms and concentration of PAM. Besides measurement of theological properties of Ca bentonite + PAM and Na bentonite + PAM systems have been examined in detail through XRD FT-IR and DTA analyses. (C) 2001 Elsevier Science B.V. All rights reserved.
Citation Count: 11
Electrical activity regulates AChR gene expression via JNK PKC zeta and Sp1 in skeletal chick muscle
(Elsevier Science Bv, 2001) Altiok, Nedret; Changeux, Jean-Pierre
Electrical activity of myotubes represses nicotinic acetylcholine receptor (AChR) gene expression. This effect is mimicked by okadaic acid and blocked by tetrodotoxin (TTX) or staurosporine in cultured myocytes [Altiok et al. EMBO J. 16 (1997) 717-725]. In this study we investigated the mechanism of this repression. We show that addition of exogenous phospholipase D (PLD) and C inhibits AChR expression in a manner which parallels that of okadaic acid. Furthermore okadaic acid caused an increase of the threonine phosphorylation of protein kinase C zeta (PKC zeta) and activator of transcription factor (ATF2) and a decrease of the phosphorylation of Sp1. All these effects were reversed by staurosporine and TTX also abolished ATF2 phosphorylation. These data reveal a possible involvement of PLD c-jun N-terminal kinase PKC zeta and Sp1 in the repression of AChR genes by electrical activity. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Citation Count: 0
Autonomic cardiac denervation reduces the incidence of atrial fibrillation after coronary revascularization
(Lippincott Williams & Wilkins, 2001) Melo, Joao; Somnez, Bingür; Tansal, Selim; Arbatlı, Harun; Ferreira, Manuel; Rebocho, Maria; Rebocho, Maria; Abecassis, Miguel; Neves, J; Calquinha, J; Dion, Robert
[Abstract Not Available]
Citation Count: 20
Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery
(Mosby Inc, 2001) Bayındır, Osman; Güden, Mustafa; Akpınar, Belhhan; Sanisoğlu, İlhan; Sağbaş, Ertan
[Abstract Not Available]
Citation Count: 0
C-reactive protein as a pre-procedural predictor of early and late outcomes of coronary angioplasty and intracoronary stent placement
(W.B. Saunders Co Ltd, 2001) Aytekin, Vedat; Aytekin, Saide; Çatakoğlu, Alp Burak; Kocazeybek, Bekir Sami; Demiroğlu, I. C. Cemşid; Demiroğlu, C
[Abstract Not Available]

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