Aryl Butenoic Acid Derivatives as a New Class of Histone Deacetylase Inhibitors: Synthesis in Vitro Evaluation and Molecular Docking Studies

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Date

2014

Authors

Esiyok, Peruze Ayhan
Seven, özlem
Eymur, Guluzar
Tatar, Gamze Bora
Erden, Didem Dayangaç
Yelekçi, Kemal
Yurter, Hayat
Demir, Ayhan S.

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Scientific Technical Research Council Turkey-Tubitak

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Abstract

New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group with a double bond in the short linker as well as metal binding groups enoic ester and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.

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Keywords

Histone deacetylase inhibition activity, Aryl butenoic acid derivatives, Molecular docking

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2

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Q4

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Volume

38

Issue

2

Start Page

338

End Page

344