Comparison of three different combination therapies in the treatment of human brucellosis

No Thumbnail Available

Date

2005

Authors

Ersoy, Yasemin
Sönmez, Emine
Tevfik, Mehmet R.
But, Ayşe Dinç

Journal Title

Journal ISSN

Volume Title

Publisher

ROYAL SOC MEDICINE PRESS LTD

Open Access Color

OpenAIRE Downloads

OpenAIRE Views

Research Projects

Organizational Units

Journal Issue

Abstract

The efficacy and tolerability of three different combination treatment regimens in human brucellosis were compared in 118 uncomplicated patients enrolled in a prospective study between May 1997 and December 2002. Brucellosis was diagnosed using standard clinical and microbiological findings. Patients with central nervous system involvement spondylitis endocarditis or children under 16 years of age were excluded from the study. Patients were randomly assigned to receive 400 mg of ofloxacin plus 600 mg of rifampicin (OR n = 41)200 mg of doxycycline plus 600 mg of rifampicin (DR n = 45) or 1 g intramuscularly streptomycin (administered for three weeks) plus 200 mg doxycycline (DS n = 32) daily for 6 weeks. All patients were followed up at least 6 months after cessation of therapy. There was no statistical difference between the groups on relapse rates and clinical response to the treatment (P> 0.05). Five patients in OR (12.8%) six patients in DR (14.3%) and three patients in DS groups (9.7%) suffered relapse. The side-effects were seen in eight (19.5%) 21 (46.7%) and eight (25.0%) patients of OR DR and DS groups respectively. The use of combination therapy of ofloxacin plus rifampicin for 6 weeks was found to be as effective as DR and DS. The side-effects of therapy in OR and DS groups was less severe than in the DR group.

Description

Keywords

Turkish CoHE Thesis Center URL

Fields of Science

Citation

35

WoS Q

N/A

Scopus Q

N/A

Source

Volume

35

Issue

4

Start Page

210

End Page

212