Comparison of Three Different Combination Therapies in the Treatment of Human Brucellosis

dc.contributor.author Ersoy, Yasemin
dc.contributor.author Sönmez, Emine
dc.contributor.author Tevfik, Mehmet R.
dc.contributor.author But, Ayşe Dinç
dc.date.accessioned 2019-06-27T08:00:51Z
dc.date.available 2019-06-27T08:00:51Z
dc.date.issued 2005
dc.description.abstract The efficacy and tolerability of three different combination treatment regimens in human brucellosis were compared in 118 uncomplicated patients enrolled in a prospective study between May 1997 and December 2002. Brucellosis was diagnosed using standard clinical and microbiological findings. Patients with central nervous system involvement spondylitis endocarditis or children under 16 years of age were excluded from the study. Patients were randomly assigned to receive 400 mg of ofloxacin plus 600 mg of rifampicin (OR n = 41)200 mg of doxycycline plus 600 mg of rifampicin (DR n = 45) or 1 g intramuscularly streptomycin (administered for three weeks) plus 200 mg doxycycline (DS n = 32) daily for 6 weeks. All patients were followed up at least 6 months after cessation of therapy. There was no statistical difference between the groups on relapse rates and clinical response to the treatment (P> 0.05). Five patients in OR (12.8%) six patients in DR (14.3%) and three patients in DS groups (9.7%) suffered relapse. The side-effects were seen in eight (19.5%) 21 (46.7%) and eight (25.0%) patients of OR DR and DS groups respectively. The use of combination therapy of ofloxacin plus rifampicin for 6 weeks was found to be as effective as DR and DS. The side-effects of therapy in OR and DS groups was less severe than in the DR group. en_US]
dc.identifier.citationcount 35
dc.identifier.doi 10.1258/004947505774938765 en_US
dc.identifier.endpage 212
dc.identifier.issn 0049-4755 en_US
dc.identifier.issn 0049-4755
dc.identifier.issue 4
dc.identifier.pmid 16354469 en_US
dc.identifier.scopus 2-s2.0-30844431530 en_US
dc.identifier.startpage 210 en_US
dc.identifier.uri https://hdl.handle.net/20.500.12469/118
dc.identifier.uri https://doi.org/10.1258/004947505774938765
dc.identifier.volume 35 en_US
dc.identifier.wos WOS:000234215000007 en_US
dc.language.iso en en_US
dc.publisher ROYAL SOC MEDICINE PRESS LTD en_US
dc.relation.journal Tropical Doctor en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 44
dc.title Comparison of Three Different Combination Therapies in the Treatment of Human Brucellosis en_US
dc.type Article en_US
dc.wos.citedbyCount 39
dspace.entity.type Publication

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